Chemical Imaging Applications

Chemical Imaging can be used in many industries to solve a variety of problems in the laboratory, quality control, quality assurance or process environments. The applications of NIR Chemical Imaging include the following:

• Non-destructive determination of pharmaceutical tablet component distribution and concentrations
• Assessment of pharmaceutical blend homogeneity
• Determining domain and particle size and distribution of chemical components in heterogeneous mixtures
• Root cause analysis and out-of-spec determinations
• Identification and discrimination of polymorphic forms
  

Published Articles:

	High-Throughput Analysis of Pharmaceutical Tablet Uniformity by Near-Infrared Chemical Imaging High-throughput measurements of NIR-CI can provide reliable tablet uniformity measurements. In this case, the mean intensity at 1600 nm per tablet from NIR-CI measurements was determined to be proportional to the API concentration.
	NIR chemical imaging for counterfeit pharmaceutical products analysis Counterfeit pharmaceutical products are a real threat to the health of patients, and to the reputation and commercial success of legitimate producers of genuine prroducts

Applications:

	Non-destructive tablet analysis Non-destructive NIR chemical imaging provides a fingerprint of the tablet’s production properties, and ultimately, its performance.
	Blend uniformity NIR Chemical Images can be analyzed statistically to measure blend homogeneity within individual tablets or between multiple tablets.
	Domain statistics calculation NIR Chemical Imaging can be used to determine domain statistics and the distribution of chemical components in heterogeneous mixtures
	Contaminant and impurity identification NIR Chemical Imaging supplies complete spectral information at each pixel and can detect even minute quantities of impurities or contaminants.
	Tablet Uniformity NIR Chemical Imaging can provide both intra- and inter-tablet uniformity data during routine manufacturing applications
	Pharmaceutical applications NIR Chemical Imaging can be used in the pharmaceutical industry to determine hydration, locate contaminants, and measure coating and layer thickness